Publications

1. Cowin AJ, Adams DH, Strudwick XL, Chan H, Hooper JA, Sander GR, Rayner TE, Matthaei KI, Powell BC, Campbell HD (2007) Flightless I deficiency enhances wound repair by increasing cell migration and proliferation. Journal of Pathology 211(5):572-581.

2. Kopecki Z, and Cowin AJ (2007) Flightless I: An actin-remodelling protein and an important negative regulator of wound repair. International Journal of Biochemistry and Cell Biology 40(8):1415-9.

3. Adams DH, Strudwick XL, Hooper JA, Matthaei KI, Powell BC, Campbell HD, Cowin AJ (2008) Gender specific effects on the actin-remodelling protein Flightless I and TGF-beta1 contribute to impaired wound healing in aged skin. International Journal of Biochemistry and Cell Biology 40(8):1555-69.

4. Kopecki Z, Arkell RM, Powell BP Cowin AJ (2009) Flightless I regulates hemidesmosome formation and integrin mediated cellular adhesion and migration during wound repair. Journal Investigative Dermatology 129:2031-2045 Commentary Kligys & Jones Flii control: balancing migration and adhesion. Journal Investigative Dermatology (2009) 129(8):1856-8.

5. Adams DH, Ruzehaji N, Strudwick XL, Greenwood JE, Campbell HD, Arkell RM, Cowin AJ (2009) Attenuation of actin-remodelling protein, Flightless I, in partial-thickness burn injuries improves wound healing via modulation of TGF-β1 and TGF-β3. British Journal Dermatology 161(2):326-36.

6. Waters JM, Lindo J, Arkell RM, Cowin AJ (2011) Regeneration of hair follicles is modulated by Flightless I (Flii) in a rodent vibrissa model. Journal Investigative Dermatology 131:838-47.

7. Kopecki Z, O’Neil G, Arkell RM, Cowin AJ (2011) Flightless I regulates focal adhesion by inhibiting paxillin phosphorylation and suppressing adhesion signalling proteins Src and p130Cas. Journal Investigative Dermatology 131(7):1450-9.

8. Thomsen N, Chappell A, Adams DA, Ali RG, Jones T, Matthaei KL, Campbell HD, Cowin AJ, Arkell RM (2011) Mouse strains for the ubiquitous or conditional overexpression of the Flii gene. Genesis 49(8):681-8.

9. Lin CH, Waters JM, Powell BC, Arkell RM, Cowin AJ (2011) Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early gestation fetal wounds improves healing. Mammalian Genome 22(5-6):341-52.

10. Kopecki Z, Arkell RM, Strudwick XL, Hirose M, Ludwig RJ, Kern JS, Bruckner-Tuderman L, Zillikens D, Murrell DF, Cowin AJ (2011) Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of Epidermolysis Bullosa Acquisita. J Pathology 225(3):401-13.

11.Jackson JE, Kopecki Z, Adams DH, Cowin AJ. (2012) Flii neutralising antibodies improve wound healing in porcine pre-clinical studies. Wound Repair and Regeneration 20:523–536

12. Lei N, Franken L, Ruzehaji N, Offenhäuser C, Cowin AJ, Murray RZ (2012) Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion Journal of Cell Science 125(18):4288-96.

13.Ruzehaji N, Grose R, Krumbiegel D, Wallace H, Stacey M, Fitridge R, Cowin AJ (2012) Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation. European Journal Dermatology 22(6):740-50.

14.Cowin AJ, Lei N, Franken L, Ruzehaji N, Offenhäuser C, Kopecki Z, Murray RZ (2012) Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation. Communicative & Integrative Biology 5(6):546-549.

15. Kopecki Z, Ruzehaji N, Turner C, Iwata H, Ludwig RJ, Zillikens D, Murrell DF Cowin AJ (2013) Topically applied Flightless I neutralising antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita. Journal Investigative Dermatology 133(4):1008-16.

16. Ruzehaji N, Mills SJ, Melville E, Arkell RM, Fitridge RA, Cowin AJ (2013) Influence of Flightless I on Toll-Like Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing. BioMed Research International 2013; 2013: 389792 (Special issue "Chronic Wounds with Emphasis in Diabetic Foot Ulcers".)

17. Ruzehaji N, Kopecki Z, Melville E, Appleby SL,. Bonder CS, Arkell RM , Fitridge R, Cowin AJ (2014) Attenuation of Flightless I improves healing in a murine model of type 1 diabetes through increased angiogenesis in the wounds. Diabetologia 57(2):402-12

18. Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ (2014) Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering. Journal of Pathology 232(5):541-52.